Too much sugar causes Alzheimer's warns Kings College

By MIA DE GRAAF FOR DAILYMAIL.COM

A diet high in sugar could lead to Alzheimer's, a new study has warned.

Unprecedented research has revealed the 'tipping point' at which blood sugar levels become so dangerous they allow the neurological disease to take hold. 

Once levels pass the threshold, they restrict the performance of a vital protein, which normally fights the brain inflammation associated with dementia.

The study by the University of Bath and King's College London builds on previous research showing diabetes appears to increase the risk of developing Alzheimer's disease and vascular dementia.

But this is the first concrete evidence to explain why abnormally high blood sugar levels, or hyperglycaemia, have an impact on cognitive function.

'Excess sugar is well known to be bad for us when it comes to diabetes and obesity, but this potential link with Alzheimer's disease is yet another reason that we should be controlling our sugar intake in our diets,' said Dr Omar Kassaar from the University of Bath. 

In Alzheimer's abnormal proteins aggregate to form plaques and tangles in the brain which progressively damage the brain and lead to severe cognitive decline.

Previous studies established glucose and its break-down products can damage proteins in cells via a reaction called glycation but the specific molecular link between glucose and Alzheimer's was not understood.

But now scientists have unraveled that link by using brain samples of 30 patients with and without Alzheimer's and tested them for protein glycation, a modification caused by high glucose levels in the blood.

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